2025
HIF-1α and VEGF Immunophenotypes as Potential Biomarkers in the Prognosis and Evaluation of Treatment Efficacy of Atherosclerosis: A Systematic Review of the Literature
Vageli D, Doukas P, Georgiou D, Prokopiou M, Ladaki N, Papadopoulou A, Doukas S, Zacharouli K, Makaritsis K, Ioannou M. HIF-1α and VEGF Immunophenotypes as Potential Biomarkers in the Prognosis and Evaluation of Treatment Efficacy of Atherosclerosis: A Systematic Review of the Literature. Frontiers In Bioscience-Landmark 2025, 30: 27004. PMID: 39862086, DOI: 10.31083/fbl27004.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factorTreatment efficacyHIF-1aUpregulation of pro-inflammatory moleculesPotential biomarkersMitogen-activated protein kinaseAttenuation of atherosclerosis progressionOverexpression of vascular endothelial growth factorVascular endothelial growth factor protein expressionIncreased VEGFVascular endothelial growth factor overexpressionLipopolysaccharide-induced tumor necrosis factor-alpha factorAtherosclerosis progressionSystematic reviewTumor necrosis factor-alphaVascular smooth muscle cellsExposure to methamphetamineAdenosine receptor antagonistHypoxia-inducible factor-1 alphaNecrosis factor-alphaNitric oxideChronic exposure to methamphetamineEndothelial growth factorSmooth muscle cellsEvaluation of treatment efficacy
2023
A Novel Saliva and Serum miRNA Panel as a Potential Useful Index for Oral Cancer and the Association of miR-21 with Smoking History: a Pilot Study.
Vageli D, Doukas P, Shah R, Boyi T, Liu C, Judson B. A Novel Saliva and Serum miRNA Panel as a Potential Useful Index for Oral Cancer and the Association of miR-21 with Smoking History: a Pilot Study. Cancer Prevention Research 2023, 16: 653-659. PMID: 37683274, DOI: 10.1158/1940-6207.capr-23-0219.Peer-Reviewed Original ResearchConceptsOral squamous cell carcinomaSerum miR-21Oral cancerMiR-136MiR-21Smoking historyPilot studySerum miRNAsEarly-stage oral squamous cell carcinomaMiR-29bSquamous cell carcinomaEarly malignant lesionsEarly-stage tumorsSerum miRNA panelFurther validationUseful indexSmoking statusCell carcinomaHealthy controlsPoor survivalTobacco useHealthy volunteersLarge cohortMalignant lesionsSmokers
2019
Biliary reflux as a causal factor in hypopharyngeal carcinoma: New clinical evidence and implications
Sasaki CT, Doukas SG, Costa J, Vageli DP. Biliary reflux as a causal factor in hypopharyngeal carcinoma: New clinical evidence and implications. Cancer 2019, 125: 3554-3565. PMID: 31310330, DOI: 10.1002/cncr.32369.Peer-Reviewed Original ResearchConceptsHuman hypopharyngeal squamous cell carcinomaAdjacent normal tissuesIL-6Reflux diseaseHypopharyngeal squamous cell carcinomaMiR-375Respective adjacent normal tissuesMiR-21Pilot studyEsophageal reflux diseaseIndependent risk factorNew clinical evidenceSquamous cell carcinomaOncomiR miR-21NF-κB activationMiR-21/miRTumor suppressor miR-375Quantitative polymerase chain reactionMessenger RNABiliary refluxHypopharyngeal carcinogenesisControl patientsLaryngopharyngeal refluxClinical evidenceHypopharyngeal carcinoma
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