Therapeutic Targeting of DNA Repair Pathways in Pediatric Extracranial Solid Tumors: Current State and Implications for Immunotherapy
Zhao S, Prior D, Heske C, Vasquez J. Therapeutic Targeting of DNA Repair Pathways in Pediatric Extracranial Solid Tumors: Current State and Implications for Immunotherapy. Cancers 2024, 16: 1648. PMID: 38730598, PMCID: PMC11083679, DOI: 10.3390/cancers16091648.Peer-Reviewed Original ResearchDNA damage repair inhibitorsPediatric extracranial solid tumorDNA damage repair deficiencyExtracranial solid tumorSolid tumorsDNA damage repairResponse to immune checkpoint blockadeCombinations of DDR inhibitorsEnhance tumor immunogenicityImmune checkpoint blockadePediatric solid tumorsTherapeutic targetPediatric clinical trialsDNA damage repair pathwaysDDR pathwaysCheckpoint blockadeTumor immunogenicityDNA damagePediatric tumorsPotential therapeutic targetDDR inhibitorsClinical trialsTumorHuman cancersRepair DNA damage
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