Metabolic rewiring in skin epidermis drives tolerance to oncogenic mutations
Hemalatha A, Li Z, Gonzalez D, Matte-Martone C, Tai K, Lathrop E, Gil D, Ganesan S, Gonzalez L, Skala M, Perry R, Greco V. Metabolic rewiring in skin epidermis drives tolerance to oncogenic mutations. Nature Cell Biology 2025, 27: 218-231. PMID: 39762578, PMCID: PMC11821535, DOI: 10.1038/s41556-024-01574-w.Peer-Reviewed Original ResearchConceptsWild-type cellsOxidative tricarboxylic acid cycleOncogenic mutationsTricarboxylic acid cycleSingle-cell resolutionMutant phenotypeMutant cellsMutant epidermisCell competitionMetabolic rewiringAcid cycleCellular redoxStem cellsMutant modelsSkin epithelial stem cellsEpidermal stem cellsContribution of glucoseEpithelial stem cellsCytosolic redoxRedox ratioMetabolic stateMutationsHrasG12VSkin epidermisCells
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